低分子肝素钙联合辛伐他汀治疗心绞痛临床分析.docVIP

低分子肝素钙联合辛伐他汀治疗心绞痛临床分析 　　作者：李国良，王建国，罗桂金 作者单位：(广东省深圳市宝安区松岗人民医院，广东 深圳　518000) 　　【摘要】 目的：探讨低分子肝素钙联合辛伐他汀治疗心绞痛的临床疗效。方法：将我院2010年1月～2010年12月收治的90例冠心病不稳定型心绞痛患者，按照治疗方法的不同分为观察组(60例)和对照组(30例)，对照组采用常规心内科治疗：吸氧、强心、利尿、抗血小板治疗、抗凝血酶治疗、钙拮抗剂等治疗。观察组在对照组的基础上采用低分子肝素钙联合辛伐他汀治疗，两组均以7 d为一个疗程。比较两组患者的临床疗效，血液流变学指标以及心绞痛发作次数、含服硝酸甘油次数、左心室射血分数以及心电图的改变。结果：观察组总有效率91.7%显著高于对照组76.7%(P0.05)。观察组治疗后的血液黏度、红细胞压积、绞痛发作次数、含服硝酸甘油次数、左心室射血分数以及心电图改变均显著优于对照组(P0.05)。两组患者均未出现皮肤黏膜出血等不良反应。结论：低分子肝素钙联合辛伐他汀治疗心绞痛可显著减少发作次数，改善血液流变学指标，疗效显著，值得临床推广。 　　【关键词】 低分子肝素钙;辛伐他汀;冠心病;心绞痛 　　[ABSTRACT] Objective： To investigate the clinical efficacy of low-molecular-weight heparin calcium combing with simvastatin on angina pectoris. Methods： A total of 90 cases of angina pectoris that admitted to our hospital during January， 2010 and December， 2009 were randomly divided into observation group (n=60) and control group (n=30). Both groups were treated with conventional therapy including oxygen inhalation， cardiac agents， diuresis and platelet antigen agents as well as calcium antagonist. But the observation group was also given extra low-molecular-weight heparin calcium combing with simvastatin. Clinical effects， hemorheology indicators， attack times of angina pectoris， needs to take oral nitroglycerin， left ventricular ejection fraction (LVEF) and changes in ECG were observed and compared between the two groups. Results： The observation group showed a total effective rate of 91.7%， significant higher than 76.7% of the control group (P0.05). After treatment， the observation group showed more obvious improvements in blood viscosity， hematocrit， angina pectoris， needs to take oral nitroglycerin， left ventricular ejection fraction (LVEF) and changes in ECG (P all 0.05). Side effects like mucocutaneous hemorrhage were not observed in neither group. Conclusions： Low-molecular-weight heparin calcium combing with simvastatin can improve hemorheology indicators， attacks times of angina pectoris， thus its an effective treatment for patients