糖尿病视网膜病变患者血清脂蛋白（α）和D二聚体水平的研究.pdfVIP

CHINESECOMMUNITYDOCTORS 论著·临床辅助检查 糖尿病视网膜病变患者血清脂蛋白(α)和D-二聚体水平的研究 梁怡 齐刚 李颖菊 441000湖北医药学院附属襄阳医院内分泌科 doi:10.3969/j.issn.1007-614x.2015.3.75 摘 要 目的：探讨不同分期糖尿病视网膜病变(DR)患者血清脂蛋白(α)[LP(a)]和D-二聚体(D-D)水平变化及意义。 方法：将126例2型糖尿病患者根据眼底检查及眼底荧光造影结果分为3组：糖尿病无视网膜病变期(NDR)、单纯型 糖尿病视网膜病变期(SDR)和增殖型糖尿病视网膜病变期(PDR)。另选40例健康者为正常对照(NC)组。测定各组患者 及健康者血清LP(α)和D-D水平，同时研究LP(α)和D-D水平的相关性。结果：LP(α)水平：NC组＜NDR组＜ SDR组＜PDR组，各组间比较差异均有统计学意义(P＜0.05)。D-D水平：NC组＜NDR组＜SDR组＜PDR组，各 组间比较差异均有统计学意义(P＜0.05)。血清LP(α)和D-D的相关性：直线相关分析表明，血清LP(α)和D-D呈正 相关(r=0.502，P＜0.01)。结论：联合检测血清LP(α)和D-D水平有助于早期诊断DR，并判断其严重程度，为临床 上通过降低血清LP(α)、D-D水平控制和延缓糖尿病视网膜病变的发展提供依据。 关键词 糖尿病视网膜病变；脂蛋白(a)；D-二聚体 Researchofserumlipoprotein(a)andD-dimerlevelsofpatientswithdiabeticretinopathy LiangYi,QiGang,LiYingju DepartmentofEndocrinology,XiangyangHospitalAffiliatedtoHubeiMedicalCollege441000 Abstract Objective:Toexplorethechangesandsignificancesofserumlipoprotein(a)[LP( α)]andD-dimer(D-D)levelsof patientswithdiabeticretinopathy(DR)indifferentstages.Methods:Accordingtofundusexaminationandfundusfluorescence angiographyresults,126patientswithtype2diabetesweredividedinto3groups:diabeteswithoutretinopathyperiod(NDR),simple diabeticretinopathyperiod(SDR)andproliferativetypediabeticretinopathyperiod(PDR).40healthypersonswereselectedasthe normalcontrolgroup(NC).TheserumLP(α)andD-Dlevelsofpatientsandhealthypersonsweredetected,andthecorrelation betweentheLP(α)andD-Dlevelswerestudied.Results:LP(α)levels:NCgroup＜NDRgroup＜SDRgroup＜PDRgroup,there werestatisticallysignificantdifferencesbetweengroupswerecompared(P＜0.05).D-Dlevels:NCgroup＜NDRgroup＜SDR group＜PDR group,there were statistically significant differences between groups were compared(P＜0.05).The correlation betweenserumLP(α)andD-D:linearcorrelationanalysisshowedthatserumLP(α)andD-Dwerepositivelycorrela