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chronicinflammation.pdf
Inflammation: Chronic Secondary article
Denis Wakefield, The University of New South Wales, Sydney, Australia Article Contents
Rakesh K Kumar, The University of New South Wales, Sydney, Australia . Introduction
. Definition
Chronic inflammation may result from failure to eliminate an acute inflammatory irritant, . Characteristics
from an autoimmune response to a self antigen, or may be caused by an innately chronic . Role of Persistent Irritant
irritant of low intensity that persists. It is characterized by simultaneous inflammation and . Inflammatory Mediators
repair, with recruitment and activation of macrophages, lymphocytes and other cells . Clinical Consequences
triggered by the coordinated action of cytokines and growth factors.
Introduction
involving tissue regeneration or repair, chronic inflamma-
Inflammation is a pattern of response to injury, in which tion is characterized by inflammation and repair occurring
cells and exudate accumulate in irritated tissues and tend to concurrently, rather than consecutively. Note that repair is
protect from further damage. It may be classified as acute always a feature of chronic inflammation because it is
associated with irritants that cause destruction of tissue
or chronic. Chronic inflammation may result from failure
of the recovery phase of acute inflammation, or may occur architecture. Repair is typically achieved by ingrowth of
as a distinct process from the outset, because of th
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