维生素D缺乏新英格兰医学.pdfVIP

T h e n e w e ng l a nd j o u r na l o f m e dic i n e review article Medical Progress Vitamin D Deficiency Michael F. Holick, M.D., Ph.D. From the Department of Medicine, Sec- nce foods were fortified with vitamin d and rickets appeared tion of Endocrinology, Nutrition, and Di- to have been conquered, many health care professionals thought the major abetes, the Vitamin D, Skin, and Bone Ohealth problems resulting from vitamin D deficiency had been resolved. How- Research Laboratory, Boston University Medical Center, Boston. Address reprint ever, rickets can be considered the tip of the vitamin D–deficiency iceberg. In fact, requests to Dr. Holick at Boston University vitamin D deficiency remains common in children and adults. In utero and during School of Medicine, 715 Albany St., M-1013, Boston, MA 02118, or at mfholick@. childhood, vitamin D deficiency can cause growth retardation and skeletal deformi- ties and may increase the risk of hip fracture later in life. Vitamin D deficiency in adults N Engl J Med 2007;357:266-81. can precipitate or exacerbate osteopenia and osteoporosis, cause osteomalacia and Copyright © 2007 Massachusetts Medical Society. muscle weakness, and increase the risk of fracture. The discovery that most tissues and cells in the body have a vitamin D receptor and that several possess the enzymatic machinery to convert th