冠心病介入治疗中应用低分子肝素与普通肝素的随机对照研究(论文资料).pdfVIP

2006 2 34 2 Chin J Cardiol, February 2006, V ol34 No2 127 陈纪林 陈珏 乔树宾 吴永健 戴军 袁晋青 秦学文 姚民 杨跃进 高润霖 ! (PC I) ( LMWH) (UFH) 2003 10 200 2 966 PCI, 966 PCI 4 [ 283 ST (ACS)] PC I 11 , LMWH UFH , LMWH 484, UFH 482LMWH ( enoxaparin), 1 mg /kg PC I 2( 12 h ), PC I 1 30 m in PCI, UFH 2 m g, PC I, 6 m g PCI 4 hLMWH UFH PC I 227 228 ( 1) LMWH 1 PCI(AM I), PCI UFH (AM I) LMWH 044% , UFH 0; ( 2) LMWH , 8, UFH 4 h, 20, , (P 00 ); ( 3) 1 LMWH 0, UFH 1AM I, PCI, 043% PCI ST ACS 2( 1 mg /kg, 12 h), 1 8 h PC I , UFH, ! ; , , ; A randomized comparative study of using enoxaparin or UFH adjunctive to percutaneous coronary intervention in patients with CHD ( ROU E ) CHEN Jilin, CHEN Jue, QIAO Shubin, WU Yong jian, DAI Jun, YUAN Jinqing, QIN X uew en, YAO M in, YAN Yuej in, AO RunlinDep artment of Cardiology, Card iovascular Institute Fuw aiHosp ita,l Ch ineseAcademy of M ed icalScience Peking Union M ed ical College, B eij ing 100037, China Corresp onding author: CHEN Jilin, Emai:l j ilinchen@ 263net Abstract! Objective To evaluate the efficacy and safety of using Enoxaparin instead of UFH for patients w ith coronary heart disease ( CHD ) underw ent coronary angiogram w ith or w ithout percutaneous coronary in tervention ( PC I) M ethods From Oct2003 to Feb200 , 966 patients w ith CHD underwent coronary angiogram ( CAG) w ere random ized to receive enoxaparin ( 1 m g/ kg subcutaneously, Q 12 h, at least wt ice beforeCAG and the sheath w asw ithdraw n mi m ediately after the procedure, n = 484) orUFH ( 2 m g, iv, beforeCAG w ith add itional 6 mg iv if PCI ind icated and the sheath w asw ithdraw n 4 hours after the procedure, n= 482) Results ∀ PC I was not perform ed in 11 patients due to m ild lesions or patients w ere suitable for C