紫草素滴丸制备工艺的研究.pdfVIP

1804 Chinese Journal of Medicinal Guide 2011 Volume 13 No.10 (Serial No.96) 药物制备 紫草素滴丸制备工艺的研究 1 2 冀文斌 ,刘涛 1 2 ( 内蒙古医学院附属人民医院,呼和浩特010050; 内蒙古医学院,呼和浩特010010) 【 】 考察紫草素滴丸的制备工艺,设计正交实验,确定最佳工艺条件。 以聚乙二醇4000为基质,二甲基硅油为冷却 摘要 目的: 方法: 剂,滴制工艺为:滴制温度85 ℃,冷却液5 ～25 ℃梯度冷却,滴距5cm,滴速40滴/min 。结果: 该工艺制得的滴丸圆整度好,丸重差异小,崩 解时限为2 1 min,符合药典规定。结论: 该工艺适合紫草素滴丸的制备。 【 】紫草素滴丸;制备;正交实验 关键词 【中图分类号】TQ460.6　 【文献标识码】A　 【文章编号】1009-0959(2011) 10-1804-02 Study on Preparation of Shikonin Dropping Pills 1 2 Ji Wen-bin ,Liu Tao 1 2 ( Peoples Hospital of Inner Mongolia Medical College, Huhhot 010050,China; Inner Mongolian Medical College,Huhhot 010010,China) 【 】 To study the technological parameters of the new drug Shikonin Dropping Pills and to establish the best ABSTRACT Objective: conditions, the preparation conditions were optimized by orthogonal design.Methods:PEG4000 was an optimal base and methyl-silicon oil was an optimal refrigerant.The preparation process was as follows: The dropping system temperature was 85 ℃, the condensate temperature was 5~25 ℃by gradient cooling, the dropping distance was 5 cm, and 40 drops/min.Results:The dropping pills made by this technology had good properties of shaping and small weight deviation .The disintegration time was 2 1 min, which conformed to the standard pharmacopoeia.Conclusions: This method is