TNF308AG单核苷酸多态性及皮肌炎相关性的Meta分析高香.pdfVIP

10162 ( )2013 11 7 22 Chin J Clinicians(Electronic Edition),November 15,2013,Vol.7,No.22  TNF-α-308A/G Meta Meta TNF-α-308A/G PubMed EBSCO EMBASE CNKI CBM α-308 TNF-α-308 Meta AA vs. GGGA vs. GG AA vs. GG GAGA AA vs. GG A vs. G 5 462 763 Meta TNF-α-308A OR2.48 95% CI2.003.07P 0.001 -308A OR2.5095% CI1.993.14P 0.001AA vs. GGGA vs. GGAA vs. GG GAGAAA vs. GG TNF-α-308A TNF-α-308A α , Meta The study of TNF-α-308A/G single nucleotide polymorphism in dermatomyositis patients--a Meta analysis GAO Xiang, LV Ling, LI Zhi-ling, BAO Li-ming, SHEN Ding-ding. Department of Rheumatology of Huashan Hospital Affiliated with Fudan University, Shanghai 200040, China Corresponding author: LV Ling, Email: huashanlvling@ Abstract Objective We detected the association of TNF-α-308A/G single nucleotide polymorphism (SNP) and dermatomyositis through Meta analysis method. Methods We searched all the publications about the association between TNF-α promoter -308A/G polymorphism and DM from PubMed, EBSCO, EMBASE, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), and Wanfang (Chinese). Meta-analysis was performed for genotypes AA versus GG, GA versus GG, AA versus GG GA, GA AA versus GG, and A allele versus G allele in a fixed/random effect model. Results A total of 5 studies (462 cases and 763 controls) were included in the current Meta-analysis. When all groups were pooled, significant association of A allele and increased DM risk was found (OR 2.48, 95% CI 2.00-3.07, P 0.001). When analyses were restricted to more race homogeneous populations, significant association of A allele with increased DM risk was found in Caucasian population (OR2.50, 95% CI1.99-3.14, P 0.001). Significant association between TNF-α p