氟尿嘧啶缓释剂对外生型年轻宫颈癌患者的疗效.pdfVIP

实用癌症杂志 20 10 9 25 5 T h e Practical Jou rnal of Can cer, Sep 20 10, V ol 25, N o. 5 4 89 喻金梅 安云婷 郭 晨 探讨氟尿嘧啶缓释 入剂对外生型年轻宫颈癌患者的临床疗效及不良反应 将同期 30例 B A 期年轻宫颈癌患者随机分为 3 组, A 组 10例采用组织间插 , B 组 10例采用 TP 方案静脉化疗, C 组 10例采用 2 瘤内氟尿嘧啶缓释 入剂监测患者放化疗后的不良反应及卵巢功能, 观察治疗 3 周后局部肿瘤的消退情况 治疗 3 周后, 3 组肿瘤体积平均缩小率分别为 60% 50% 60% , 3 组比较差异无显著性 (P 0. 05) ; B 组不良反应最大, C 组未出现不良反应, A 组治疗后 FSHLH 水平升高, E2 水平下降, 出现卵巢功能减退, 与其余 2 组比较, 有统计学差异( P 0. 05) 氟尿嘧啶缓释 入剂对外生型宫颈癌的疗效较好, 不良反应轻, 特别是未减弱卵巢功能 氟尿嘧啶缓释 入剂; 外生型年轻宫颈癌; 临床疗效; 不良反应; 卵巢功能 : R 737. 33 : A : ( 2010) 0504 890 3 TheClinical Efficacy of Fluorouracil Sustained- release Implants In the Treatm ent of YoungerW omen with Exophytic CervicalCarcinoma YUJ inm e,i AN Yunting, GUOChen. R ep roductive C enter of J iangx i P rov incial Ch ildren and M aternal H o p ital, N anchang, 330029 Abstract bjective T o investiga te the clin ica l eff icacy and adverse reac tions o f fluo rouracil su sta ined- re lease mi p lants in the treatm ent of younger w om en w ith exophy tic cerv ica l carc inom a. M ethods 30 patients w ith the sam e per iod B - 2 A ce rv ica l cancer w ere random ly d iv ided into 3 g roup s. G roup A ( 10 cases o f irrad ia tion) rece ived a preoperativ e interstitia l mi plant irradiation. G roup B ( 10 cases o f pre- chemo the rapy ) rece ived TP prog ram to g ive intrav enou s chemo therapy. G roup C ( 10 cases) received fluorou rac il su sta ined- re lease mi plants. A cute adverse reactions w ere eva luated a fter the treatm ent, and tumo r responses w ere eva luated 3 w eeks afte r the treatm ent. T he ovar ian ho rmone leve ls w ere detected 3 m ont