515例妇女高危型HPV感染检测结果分析.pdf

954 中国肿瘤临床 2011 年第38 卷第16期 515例妇女高危型HPV感染检测结果分析 李世霞 了解高危型人乳头瘤病毒（HPV）在妇女中的感染情况。 将健康体检妇女以年龄40 岁为界分为2 个实验 摘要 目的： 方法： 组：低年龄组（40 岁）和高年龄组（≥40 岁），应用高危型人乳头瘤病毒多重核酸扩增荧光定量检测技术对515 例健康体检妇女进 行高危型HPV 感染检测，比较低年龄组和高年龄组之间高危型HPV 感染情况，对结果进行统计学分析。 515 例健康体检妇 结果： 女中，高危型HPV 感染总阳性率为8.54% （44/515 ），低年龄组和高年龄组高危型HPV 感染率分别为3.45% （3/87）和9.58% （41/ 428 ），高年龄组高危型HPV 感染阳性率高于低年龄组（P0.05 ），高危型HPV 感染阳性率在40 岁以上妇女感染率较高。 40 结论： 岁以上妇女为高危型HPV 感染高发人群，加强高危型HPV 检测对降低该人群宫颈癌的发生率和致死率至关重要。 关键词 人乳头瘤病毒 荧光定量PCR 感染 年龄 doi:10.3969/j.issn. 1000-8179.2011.16.007 Case Study of 515 Women with High-risk Human Papillomavirus Infection Shixia LI Correspondence to: Shixia LI, E-mail: lishixia@ Center for Preventive Medicine, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Treatment of Tianjin City, Tianjin 300060, China Abstract Objective: To investigate the infection status of high-risk human papillomavirus ( HPV ) in women. Methods: The study group consisting of 515 healthy women was divided into two experimental groups. One was the low-age group ( 40 years old ), and the other was the high-age group ( ≥40 years old ). The infection status of high-risk HPV was determined by the multiplex poly- merase chain reaction fluorescence detection technology. The results of the two groups were compared and statistically analyzed. Re- sults: The total high-risk HPV-positive rate for the entire study group was 8.54% ( 44/515 ). The positive rate was 3.45% ( 3/87 ) fo