2694-ftp.pdf

PHYTOTHERAPY RESEARCH Phytother. Res. 23, 658–665 (2009) Published online 23 December 2008 in Wiley InterScience 658 J. Y-W. CHAN ET AL. () DOI: 10.1002/ptr.2694 Antihyperglycemic and Antioxidative Effects of a Herbal Formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii in a Mouse Model of Type 2 Diabetes Mellitus 1,2 1 1 3 Judy Yuet-Wa Chan , Fung-Chun Lam , Ping-Chung Leung , Chun-Tao Che and Kwok-Pui Fung1,2* 1Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China 2Department of Biochemistry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China 3School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China There is emerging evidence that the generation of reactive oxygen species (ROS), which leads to dysfunction ββ of pancreatic β-cells, is a major factor in the development of type 2 diabetes mellitus. Antioxidation is one of ββ the therapeutic strategies to overwhelm the imbalance in ROS production. In this study, a herbal formulation SR10, comprising Radix Astragali, Radix Codonopsis and Cortex Lycii, was examined for its antidiabetic and ++ ++ antioxidative effects using the diabetic +db/+db mouse model. The results showed that SR10 was effective in ++ ++ ββ