《silicone in pharmaceutical applications_Dowcorning》.pdf

Silicones in Pharmaceutical Applications André Colas, Dow Corning Dow Corning Healthcare Industries Silicones in Pharmaceutical Applications André Colas, Dow Corning 1. Introduction The name silicone encompasses a large number of compounds based on polydialkylsiloxanes; amongst them, the most common are the trimethylsilyloxy- terminated polydimethylsiloxanes of the structure: Me Me Me Me Si O (Si O) Si Me or Me SiO (SiMe O) SiMe where n = 0, 1, ... n 3 2 n 3 Me Me Me These are linear polymers, liquid even at very high molecular weights. Numerous other structures can easily be obtained, either by substitution of methyl groups by other groups like -CH = CH , -H, -CH -CH -CF or by replacing some of the 2 2 2 3 Me SiO chain units with MeSiO or SiO units where the silicon is substituted 2 2/2 3/2 4/2 with 3 or 4 oxygens to give non-linear branched structures (1). The preferred