黄芪多糖对2型糖尿病大鼠肾组织胰岛素信号转导的影响.pdfVIP

26 2 ( ) V ol . 26 N o. 2 2005 3 M edical J ournal o f Wuhan U niv er sity M ar, 2005 黄芪多糖对2 型糖尿病大鼠肾组织 胰岛素信号转导的影响 周云枫 吴 勇 欧阳静萍 4 30071 目的 ( A PS) 2 方法 Wistar ( Contro l ) ( ST Z) ( D M ) ( DM + A PS ) , 5 , , ( In sR ) 1( IRS1) 3 ( PI3K ) 结果 DM Co nt rol DM + A PS , ( P 0 . 0 1) ; DM DM + AP S Contr ol ( P 0 . 01) , DM + A PS DM ( P 0. 0 1) ; ( P 0 . 05) ; DM InsRIRS1 PI3K Contro l DM + A PS ( P 0 . 05) 结论 2 , In sRI RS1PI3K , , ; 2 ; ; 1; 3 R 587. 1 A 167 18852( 2005) Effects of Astragalus Polysaccharide on Insulin Signal Transduction in Renal Tissue of Type 2 Diabetic Rats Zhou Yunfeng, WuYong, uyangJingping D ep t . of P at hop hy s iol ogy , School of M ed ici ne, Wuhan Un iv ers i ty , Wuhan 430071, Chi na Abstract bjective: T o invest igate eff ect s o f ast ragalu s poly saccharide( A P S) on ex pres sion of insulin signal m olecules in renal t is su e of t yp e 2 diabet ic rat s. Methods: W ist ar rat s w ere div ided int o no rmal cont rol g roup ( contr ol gro up) , st rept ozo to cin ( ST Z) indu ced diabet ic m odel gro up ( DM group) and diabet ic mo del plu s ast rag alus poly saccharide t herapy g roup( D M+ A PS group) at ran dom. Af t er 5 w eek s, t he general behavior s of t he rat s w ere observed bef ore t hey w ere killed , and their blood w as ext racted for measuring t he levels of glu cose and serum in sulin. Im muno histo chem ist ry w as applied t o det ect t he ex pr es sion lev els of In sR , IRS1 and P I3K in renal t issue. Re sults: T he w eight