超声辐射下-烷基吲哚衍生物的合成.pdfVIP

摘 要 摘 要 综述了近五年来 3-烷基吲哚衍生物的合成进展。利用超声辐射，改进了二吲哚甲烷 和吲哚醇的合成，并合成了一种新的具有热敏荧光性含有二吲哚甲烷基的聚合物。 采用超声辐射的方法，以 K10-ZnCl2 为催化剂，由吲哚与环氧查尔酮反应合成了 吲哚醇；以十二烷基苯磺酸为催化剂，探索了吲哚与醛在水溶液中合成二吲哚甲烷的反 应。反应条件温和、反应时间短、收率高。 通过六步反应合成了含有二吲哚甲烷基的水溶性聚合物 Indole-PNIPAAm，并用超 声辐射方法改进了聚合物中间体的合成。利用紫外吸收和荧光发射等方法对其热敏荧光 性能进行了表征，结果表明该聚合物具有良好的热敏荧光性能，且随着温度的变化具有 可逆性。 关键词 超声辐射 吲哚醇 二吲哚甲烷 吲哚-聚异丙基丙烯酰胺 热敏性 I Abstract Abstract The progress in synthesis of 3-alkylindole derivatives from indoles was reviewed in recent five years. The synthesis of bis(indolyl)methanes and βindolylalcohols were improved by ultrasound irradiation, simultaneity, a new fluorescent thermosensitive polymer possessing bis(indolyl)methanyl was synthesized. βindolylalcohols were synthesized via the reaction of indole with 2,3-epoxyl-1,3-diaryl-1-propanone catalyzede by K10-ZnCl2 under ultrasound irradiation. Synthesis of bis(indolyl)methanes via the reaction of indole with aromatic and ketones catalyzed by ABS in aqueous solution was carried out under unltrasound irradiation. Our procedure is characterized by mild conditions, short reaction time, high yield. A new water-soluble polymer of indole (indole-PNIPAAm) possessing bis(indolyl)methanyl was synthesized via six steps and the synthesis of intermediate of the polymer was improved by ultrasound irradiation. Characterization of indole-PNIPAAm by UV and fluorescence spectrophotometry measurements revealed that it was excellent in both temperature-sensitive and fluorescence properties and the respon