《莫索尼定滴眼液点眼对家兔眼压及血压的影响2016年论文》.pdfVIP

眼科研究2010年7月第28卷 7魈 611 · 实 验 研 究 · 莫索尼定滴眼液点眼对家兔眼压及血压的影响 张倩 孙乃学 刘健 Effectoftopicallyapplied moxonidineon intraocularpressure andblood pressure ZHANGQian，SUNNai—xue，LIUJian．DepartmentofOphthalmology，Xi’anNo．4Hospital，Xi’an710004， China Abstract Background Moxonidineisanagonistof 2receptor．Ithasbeenused to theclinicaltreatmentofglaucoma． Therefore，theeffectsofmoxonidineon oculartissueand blood pressure and heartrate isalso interested research topic． 0bjective ThisstudywastoevaluatetheeffectsofdifferentconcentrationsofmoxonidineOllintraocularpressure(1OP)，pupil diameter(PD)，heartrate (HR)andbloodpressure (BP)simuhaneouslyaftertopicaladministration． Methods 0．05％， 0．1％ ．0．2％ moxonidineweretopicallyused inthelateraleyesofhealthywhiterabbitsin0．05％ moxonidinegroup (8 rabbits)，0．1％ moxonidinegroup(8rabbits)，0．2％ moxonidinegroup(8rabbits)respectivelyandsterilizeddistilledwaterwas topicallyusedinthecontrolgroup(8rabbits)．IOPoftherabbitswasmeasuredbypunctureofanteriorchamberwith41／2gauge needleconnectingphysiologicalrecorder，andthediameterofpupilwasmeasuredusingrulerbeforeusageofthedrugand0．5，1， 2，3，4，5，6，7，8 hoursafter application ofthe drug．BP and HR ofthe rabbitsweredetected with carotid artery catheter recorder． Results Moxonidinecaused dose—dependentdecreases in IOP．The maximum decreases in IOP were 3．01mmHg (18．3I％)．3．70mmHg(22．13％)，4．46mmHg(25．60％)andocularhypotensionlastedfor6，8andover8hoursinipsilateral eyesatthethreedosesofmoxonidinerespectively．In thecontralateraleyestheduration ofocularhypotensionwereshorter，the maximum decreasesinIOPwere2．64mmHg(15．46％)，3．10mmHg(18．82％)and2．62mmHg(16．48％)respectively．All dosesofMOXcausedsignificantincreasesinPD (themaximum increaseswere2．6Innl，3．2mmand3．9inm)inipsilate