辛伐他汀对糖尿病大鼠视网膜血管内皮钙黏蛋白表达的影响.pdfVIP

·325· ·实验研究· 辛伐他汀对糖尿病大鼠视网膜血管内皮钙黏蛋白 表达的影响 萧 鸿 王志云 庞东渤 刘学政 sinvastatinon inretinasofratwithdiabetes Effectof VE．cadherin Xiao First Hong，WangZhiyun，P口增Dongbo，LiuXuezheng．DivisionofTeachingAffairs，AffiliatedHospital， Medical Liaoning University，Jinzhou121001，China ofdiabetic the of retinalblood Abstract The mechanism is of Backgroundprimary retinopathychangepermeability connectionisthe modeofintercellularconnectionretinal endothelial capillary．Adhesion predominant among capillary cells，and vascularendothelium—cadherinmediatestheadhesionofvascularendothelialcellsto maintainthe ofintercellular stability connectionandcell Theaimofthe isto the ofVE·cadherinintheretinaof gap．Objective presentstudy expression investigate andassess onthe ofVE—cadherin diabetes theeffectofsimvastatin streptozotocin(STZ)-inducedmellitus(DM)rat expression andthe ofsimvastatininthe ofdiabetic MethodsDiabeticmodelswere non—lipidtherapy pathogenesis retinopathy． establishedin48SDrats the of administered by streptozotocin(STZ)．Simvastatin(20 intraperitonealin