《PET显像剂18F-NaF骨骼分布的实验研究》.pdfVIP

· 76· SouthMed 南方医科大学学报(J Univ) 2008；28(1) PET显像剂·8F’-NaF骨骼分布的实验研究 广州510515) 摘要：目的探讨-8F．NaF在骨质疏松症实验研究中的应用价值。方法用过量地塞米松磷酸钠注射法制作大鼠骨质疏 松模型，对动物模型注射1SF．NaF，进行生物分布研究，测定大鼠各器官对，8F．NaF的摄取值。对8例健康志愿者进行胸 在注射后．20 取达峰值。60 理想的骨血流和代谢显像剂，18F．NaF在正常骨和实验性骨质疏松症骨骼中的分布有明显差异，提示1昝．NaF在骨质疏 松症的研究中具有潜在应用价值。 关键词：-SF_NaF；生物分布；正电子发射计算机断层显像；骨质疏松症 ’ 中图分类号：R981．1 文献标识码：A 文章编号：1673．4254(2008)01．0076．03 Biodistributionof18F—NaFasan in ratsfor imagingagentosteoporoticposition tomography WANG Pen91，LIQin-zon92，WANGMing-fan93 ofTraditional ofTraditional Chinese Chinese DepartmentofCardiology，NanfangHospitall，Department Orthopedics，College Medicine2， PETCenter Medical 510515，China ofNanfangHospital3，SouthemUniversity,Guangzhou To thebiodistributionof18F-NaFasan for emission Abstract：Objectiveinvestigate imagingagentposition tomography ratmodelsof Methods wasinducedin10ratsvia with811excessof (PET)in osteoporosis． Osteoporosis injection dexamethasone thebioistributionof1叩-NaFintheratswas another10normalratsasthe sodium，and studied，with phosphate control PETwasalso in8 volunteers．andthe of18F-F·inthebonetissueswere group．18F_NaF performedhealthy uptakes withthecontrol measured．Results ratsshowed decreased Compared rats，theosteoporotic significantly18F—F·uptake， inthefemoral 7thribandthe chestPET inthe especially neck，lumbarvertebr