Overexpression+of+brain-derived+neurotrophic+factor+in+the+hippocampus+protects+against+post-stroke+depression.pdf
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Overexpression+of+brain-derived+neurotrophic+factor+in+the+hippocampus+protects+against+post-stroke+depression.pdf
NEURAL REGENERATION RESEARCH
September 2015,Volume 10,Issue 9
RESEARCH ARTICLE
Overexpression of brain-derived neurotrophic factor
in the hippocampus protects against post-stroke
depression
1 1 2 2 3 3 1 1, *
Hao-hao Chen , Ning Zhang , Wei-yun Li , Ma-rong Fang , Hui Zhang , Yuan-shu Fang , Ming-xing Ding , Xiao-yan Fu
1 Medical Molecular Biology Laboratory, School of Medicine, Jinhua Polytechnic, Jinhua, Zhejiang Province, China
2 Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China
3 Center of Experimental Animals, Jinhua Food and Drug Administration, Jinhua, Zhejiang Province, China
Abstract
*Correspondence to: Post-stroke depression is associated with reduced expression of brain-derived neurotrophic
Xiao-yan Fu, M.D., fxythd@. factor (BDNF). In this study, we evaluated whether BDNF overexpression affects depression-like
behavior in a rat model of post-stroke depression. The middle cerebral artery was occluded to
orcid: produce a model of focal cerebral ischemia. These rats were then subjected to isolation-housing
0000-0001-5496-7944 (Xiao-yan Fu) combined with chronic unpredictable mild stress to generate a model of post-stroke depression.
A BDNF gene lentiviral vector was injected into the hippocampus. At 7 days after injection,
doi: 10.4103/1673-5374.165510 western blot assay and real-time quantitative PCR revealed that BDNF expression in the hippo-
/
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