Polylactic-co-glycolic+acid+microspheres+containing+three+neurotrophic+factors+promote+sciatic+nerve+repair+after+injury.pdf

NEURAL REGENERATION RESEARCH September 2015,Volume 10,Issue 9 RESEARCH ARTICLE Polylactic-co-glycolic acid microspheres containing three neurotrophic factors promote sciatic nerve repair after injury 1 2 2 3 2 2 2 4, * Qun Zhao , Zhi-yue Li , Ze-peng Zhang , Zhou-yun Mo , Shi-jie Chen , Si-yu Xiang , Qing-shan Zhang , Min Xue 1 Health Management Center, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China 2 Department of Orthopedics, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China 3 Department of Orthopedics, Yiyang Municipal Central Hospital, Yiyang, Hunan Province, China 4 Department of Gynecology , Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China Abstract *Correspondence to: A variety of neurotrophic factors have been shown to repair the damaged peripheral nerve. Min Xue, Ph.D., xuemin5908@ However, in clinical practice, nerve growth factor, neurotrophin-3 and brain-derived neuro- trophic factor are all peptides or proteins that may be rapidly deactivated at the focal injury site; orcid: their local effective concentration time following a single medication cannot meet the required 0000-0003-4369-8747 (Min Xue) time for spinal axons to regenerate and cross the glial scar. In this study, we produced polymer sustained-release microspheres based on the polylactic-co-glycolic acid copolymer; the micro- doi: 10.4103