PTEN+inhibition+and+axon+regeneration+and+neural+repair.pdfVIP

NEURAL REGENERATION RESEARCH September 2015,Volume 10,Issue 9 INVITED REVIEW PTEN inhibition and axon regeneration and neural repair * Yosuke Ohtake, Umar Hayat, Shuxin Li Shriners Hospitals Pediatric Research Center, Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA Abstract *Correspondence to: The intrinsic growth ability of all the neurons declines during development although some may Shuxin Li, M.D., Ph.D., grow better than others. Numerous intracellular signaling proteins and transcription factors Shuxin.li@. have been shown to regulate the intrinsic growth capacity in mature neurons. Among them, PI3 kinase/Akt pathway is important for controlling axon elongation. As a negative regulator of this doi: 10.4103/1673-5374.165496 pathway, the tumor suppressor phosphatase and tensin homolog (PTEN) appears critical to con- / trol the regenerative ability of young and adult neurons. This review will focus on recent research progress in axon regeneration and neural repair by PTEN inhibition and therapeutic potential Accepted: 2015-05-16 of blocking this phosphatase for neurological disorders. Inhibition of PTEN by deletion in con- ditional knockout mice, knockdown by short-hairpin RNA, or blockade by pharmacological approaches, including administration of selective PTEN antagonist peptides, stimulates various degrees of axon regrowth in juvenile or adult rodents with central nervous sys