Rho激酶活性与系统性红斑狼疮疾病活动的相关性研究.pdfVIP

Journal of Practical Dermatology, Aug. ,Vol. No.4 241 实用皮肤病学杂志 2015年8月第8卷第4期 2015 8 • 论　著 • Rho激酶活性与系统性红斑狼疮疾病活动的 相关性研究 彭世光，符 颖，李 莉，何焱玲 [ 摘要 ]　 目的　探讨 Rho 激酶（Rho kinase, ROCK ）活性与系统性红斑狼疮（SLE）疾病 彭世光 活动度的相关性。方法　采用蛋白质印迹法（Western blot ）检测 SLE 患者和健康受试者 的ROCK 活性，SLE 疾病活动指数 2000 （SLEDAI-2000，SLEDAI-2K）评分评估 SLE 患 者疾病活动程度，应用 SPSS17.0 统计软件分析 ROCK 活性与 SLEDAI-2K 评分的相关性。 结果 SLE 疾病轻度、中度及重度活动组患者 ROCK 活性均明显高于健康受试者，中度和 重度活动组患者 ROCK 活性显著高于轻度活动组；中度活动组与重度活动组患者的 ROCK 活性相比差异无统计学意义；ROCK 活性与 SLEDAI-2K 评分呈相关性。结论　ROCK 活 性与 SLE 疾病活动度相关，可作为一种新的潜在的 SLE 疾病活动度评估指标。 [ 关键词 ]　红斑狼疮，系统性；Rho 激酶；疾病活动度 [中图分类号]　R593.241　　[文献标识码] A　　[文章编号]　 1674-1293(2015)04-0241-04 ROCK activity correlates with SLE disease activity PENG Shi-guang ，FU Ying ，LI Li ，et al Department of Dermatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China [Abstract]　Objective　To investigate the correlation between Rho kinase(ROCK) activity and systemic Lupus erythematosus(SLE) disease activity. Method　ROCK activity of SLE patients and healthy volunteers was test by Western blotting. SLE disease activity was evaluated by SLEDAI-2K score. The correlation between ROCK activity and SLE disease activity was analyzed via SPSS17.0 software. Result　ROCK activities of the mild, moderate and severe active group of SLE patients were all greater than healthy volunteers. ROCK activities of the moderate and severe active group of SLE patients were both greater than the mild active group. There was no difference in the ROCK activity between the moderate and severe active group of SLE patients. ROCK activity also correlated with SLEDAI-2K scores. Conclusion　ROCK activity which correlated with SLE disease activity may be a new potential marker of SLE disease ac