Probiotics for the treatment of upper and lower respiratory-tract infections in children systematic review based on randomized clinical trials》.pdfVIP

J Pediatr (Rio J). 2015;91(5):413427 .br REVIEW ARTICLE Probiotics for the treatment of upper and lower respiratory-tract infections in children: systematic review based on randomized clinical trials Georgia Véras de Araujo a,b,c,∗ , Mário Henriques de Oliveira Junior a,d , Décio Medeiros Peixotoa,c,e , Emanuel Sávio Cavalcanti Sarinho a,c,e,f a Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil b Hospital das Clínicas, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil c Centro de Pesquisas em Alergia e Imunologia, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil d Department of Internal Medicine, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil e Department of Pediatrics, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil f Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil Received 30 January 2015; accepted 19 March 2015 Available online 6 June 2015 KEYWORDS Abstract Children; Objectives: Evaluate the effect of probiotics on the symptoms, duration of disease, and the occurrence of new episodes of upper and lower respiratory infections in healthy children. Respiratory tract infections; Sources: In order to identify eligible randomized controlled trials, two reviewers accessed Probiotics four electronic databases [MEDLINE/PubMed, Scopus (Elsevier), Web of Science, and Cochrane (Cochrane VHL)], as well as ClinicalT until January 2015. Descriptors were determined by using the Medical Subject Headings tool, following the same search protocol. Summary of the findings: Studies showed to be heterogeneous rega