Probiotics for the treatment of upper and lower respiratory‐tract infections in children systematic review based on randomized clinical trials》.pdf

J Pediatr (Rio J). 2015;91(5):413427 .br ARTIGO DE REVISÃO Probiotics for the treatment of upper and lower respiratory-tract infections in children: systematic review based on randomized clinical trials Georgia Véras de Araujo a,b,c,∗ , Mário Henriques de Oliveira Junior a,d , Décio Medeiros Peixotoa,c,e e Emanuel Sávio Cavalcanti Sarinho a,c,e,f a Universidade Federal de Pernambuco (UFPE), Recife, PE, Brasil b Hospital das Clínicas, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brasil c Centro de Pesquisas em Alergia e Imunologia, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brasil d Departamento de Medicina Interna, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brasil e Departamento de Pediatria, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brasil f Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brasília, DF, Brasil Recebido em 30 de janeiro de 2015; aceito em 19 de março de 2015 KEYWORDS Abstract Children; Objectives: Evaluate the effect of probiotics on the symptoms, duration of disease, and the Respiratory tract occurrence of new episodes of upper and lower respiratory infections in healthy children. infections; Sources: In order to identify eligible randomized controlled trials, two reviewers accessed four electronic databases [Medline/PubMed, Scopus (Elsevier), Web of Science, and Cochrane (Coch- Probiotics rane VHL)], as well as ClinicalT until January of 2015. Descriptors were determined by using the Medical Subject Headings tool, following the same search protocol. Summary of the findings: Studies showed to be heteroge