Properties and functions of TRPM1 channels in the dendritic tips of retinal ON-bipolar cells》.pdf

European Journal of Cell Biology 94 (2015) 420–427 Contents lists available at ScienceDirect European Journal of Cell Biology j o u r n a l h o m e p a g e: w w w. elsev /locate/ejcb Mini Review Properties and functions of TRPM1 channels in the dendritic tips of retinal ON-bipolar cells Franziska M. Schneider, Florian Mohr, Marc Behrendt, Johannes Oberwinkler ∗ Institut für Physiologie und Pathophysiologie, Philipps-Universität Marburg, Deutschhausstr. 1-2, D-35037 Marburg, Germany a r t i c l e i n f o a b s t r a c t Keywords: An increase in light intensity induces a depolarization in retinal ON-bipolar cells via a reduced gluta- TRPM1 mate release from presynaptic photoreceptor cells. The underlying transduction cascade in the dendritic Retina tips of ON-bipolar cells involves mGluR6 glutamate receptors signaling to TRPM1 proteins that are an ON-bipolar cells indispensable part of the transduction channel. Several other proteins are recognized to participate in Synapse the transduction machinery. Deficiency in many of these leads to congenital stationary night blindness, Congenital stationary night blindness (CSNB) because rod bipolar cells, a subgroup of ON-bipolar cells, constitute the main route for sensory infor- G-protein-coupled signaling mation under scotopic conditions. Here, we review the current knowledge about TRPM1 ion channels