Pulsed Focused Ultrasound Treatment of Muscle Mitigates Paralysis-Induced Bone Loss in the Adjacent Bone A Study in a Mouse Model》.pdf

Ultrasound in Med. Biol., Vol. 40, No. 9, pp. 2113–2124, 2014 Copyright 2014 World Federation for Ultrasound in Medicine Biology Printed in the USA. All rights reserved 0301-5629/$ - see front matter /10.1016/j.ultrasmedbio.2014.02.027 d Original Contribution PULSED FOCUSED ULTRASOUND TREATMENT OF MUSCLE MITIGATES PARALYSIS-INDUCED BONE LOSS IN THE ADJACENT BONE: A STUDY IN A MOUSE MODEL SANDRA L. POLIACHIK,*y TATIANA D. KHOKHLOVA,yz YAK-NAM WANG,y JULIANNA C. SIMON,y and MICHAEL R. BAILEYy *Department of Radiology, Seattle Children’s Hospital, Seattle, Washington, USA; y Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington, USA; and z Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington, USA (Received 24 July 2013; revised 19 February 2014; in final form 20 February 2014) Abstract—Bone loss can result from bed rest, space flight, spinal cord injury or age-related hormonal changes. Current bone loss mitigation techniques include pharmaceutical interventions, exercise, pulsed ultrasound tar- geted to bone and whole body vibration. In this study, we attempted to mitigate paralysis-induced bone loss by applying focused ultrasound to the midbelly of a paralyzed muscle. We employed a