原创力文档Putative mechanisms of action of probucol on high-density lipoprotein apolipoprotein A-I and its isoproteins kinetics in rabbits》.pdf
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Putative mechanisms of action of probucol on high-density lipoprotein apolipoprotein A-I and its isoproteins kinetics in rabbits》.pdf
Biochimica et Biophysics Acta, 1047 (1990) 241-254 247
Elsevier
BBALIP 53531
Putative mechanisms of action of probucol on high-density
lipoprotein apolipoprotein A-I and its isoproteins kinetics
in rabbits
Hong Ying ‘, Keijiro Saku I, Ryoko Harada ‘, Noboru Takami 2, Norihiro Sasaki 3,
Yasushi Saito 4 and Kikuo Arakawa ’
’De~~tment of Internal Medicine, 2 ~ad~ojsotoFeCenter, Fukuoka University School of Medicine, Fukuoka,
3Kawatetsu Chiba Hospital, Chiba and 4 Department of ~niernal Medicine,
Chiba University School of Medicine, Chiba (Japan)
(Received 13 March 1990)
(Revised manuscript received 18 July 1990)
Key words: Apolipoprotein A-I; Cholesterol ester transfer activity; Fractional catabolic rate; HDL; Isoprotein; Rabbit;
Turnover study
Probucol is a widely prescribed lipid-lowering agent, the major effects of which are to lower chotestero1 in both low- and
high-density lipoproteins (LDL and HDL, respectively). The mechanism of action of probucol on HDL apolipoprotein
(apo) A-I kinetics was investigated in rabbits, with or without c
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