Qualitative and quantitative characterization of chemical constituents in Xin-Ke-Shu preparations by liquid chromatography coupled with a LTQ Orbitrap mass spectrometer》.pdfVIP

Journal of Pharmaceutical and Biomedical Analysis 55 (2011) 984–995 Contents lists available at ScienceDirect Journal of Pharmaceutical and Biomedical Analysis j o u rn al h omepage: w w w. elsev /locate/jpba Qualitative and quantitative characterization of chemical constituents in Xin-Ke-Shu preparations by liquid chromatography coupled with a LTQ Orbitrap mass spectrometer Jing-Bo Peng a , Hong-Mei Jia a , Yue-Tao Liu a , Hong-Wu Zhang a , Shu Dong b , Zhong-Mei Zou a,∗ a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, No. 151 Malianwa North Road, Haidian District, Beijing 100193, PR China b Beijing University of Chemical Technology, Beijing 100029, PR China a r t i c l e i n f o a b s t r a c t Article history: Xin-Ke-Shu (XKS), a traditional Chinese medicine (TCM) preparation containing five herbal medicines, Received 16 February 2011 has been commonly used for the treatment of coronary heart disease in China. However, the chemical Received in revised form 30 March 2011 constituents in XKS have not been clarified yet. In order to quickly define the chemical profiles and con- Accepted 30 March 2011 trol the quality of XKS preparations, liquid chromatography coupled with electrospray ionization hybrid Available online 7 April 2011 linear trap quadrupole orbitrap (LC–LTQ-Orbitrap) mass spectrometry was applied for simultaneous iden- tificati