Raf kinase inhibitor protein mediated signaling inhibits invasion and metastasis of hepatocellular carcinoma》.pdf

BBAGEN-28233; No. of pages: 8; 4C: 3, 5, 6 Biochimica et Biophysica Acta xxx (2015) xxx–xxx Contents lists available at ScienceDirect Biochimica et Biophysica Acta journa l homepage: /locate/bbagen 1Q1 Raf kinase inhibitor protein mediated signaling inhibits invasion and 2 metastasis of hepatocellular carcinoma 3Q2 Xiaohui Wu a,1, Yongjiang Yang b,1, Zhuo Xu a, Jiankun Li a, Baoming Yang a, Ningning Feng a, F 4 Yueshan Zhang a, Shunxiang Wang a,⁎ 5Q3 a Department of Hepatobiliary Surgery, The Fourth Hospital of Hebei Medical University, China O 6 b Department of Oncological Surgery, The First Hospital Affi liated to Hebei Institute of North, China O 7 a r t i c l e i n f o a b s t r a c t R 8 Article history: Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality and 19 9 Received 14 March 2015 poor prognosis. Mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) signaling pathways 20 10 Received in revised form 17 June 2015 have been implicated in promoting tumor cell proliferation and invasion of HCC cells. 21 P 11 Accepted 22 June 2015 Methods: As a potential inhibitor of tumor m