Reduced activation and CD3 lymphocyte recruitment after TNF-inhibitor use evaluation of clinical and 99mTc-OKT3 scintigraphic response in a patient with juvenile idiopathic arthritis》.pdf

RBRE-221; No. of Pages 5 ARTICLE IN PRESS r e v b r a s r e u m a t o l . 2 0 1 5;x x x(x x) :xxx–xxx REVISTA BRASILEIRA DE REUMATOLOGIA w w w. reumato log ia.c om .br Case report Reduced activation and CD3 lymphocyte recruitment after TNF-inhibitor use: evaluation of clinical and 99mTc-OKT3 scintigraphic response in a patient with juvenile idiopathic arthritis Flavia Paiva Proenc¸a Lobo Lopes a, Sergio Augusto Lopes de Souza a,∗, Blanca b a Elena Rios Gomes Bica , Lea Mirian Barbosa da Fonseca , Mario Newton Leitão de Azevedo b, Bianca Gutfilen a a Cell and Molecule Labelling Laboratory (CMLL), Department of Radiology, Medicine School, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil b Department of Rheumatology, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil a r t i c l e i n f o a b s t r a c t Article history: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatologic disease Received 5 August 2014 observed in children up to 16 years. It is known that JIA occurs due to a chronic joint inflam- Accepted 1 March 2015 mation that involves a cascade of responses amongst which the involvement of CD3 complex Available online xxx can be cited. CD3 molecular complex must be present on T lymphocyte so that the receptor can be expressed by the cell and activate it. In the juv