Relation of High-Density Lipoprotein CholesterolApolipoprotein A-I Ratio to Progression of Coronary Atherosclerosis in Statin-Treated Patients》.pdf

Relation of High-Density Lipoprotein Cholesterol:Apolipoprotein A-I Ratio to Progression of Coronary Atherosclerosis in Statin-Treated Patients a b a a Preethi Mani, MD , Kiyoko Uno, MD, PhD , Julie St. John, MS , E. Murat Tuzcu, MD , Steven E. Nissen, MDa, and Stephen J. Nicholls, MBBS, PhDb,* High-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) levels are inversely associated with adverse cardiovascular outcomes. Associations between these HDL-Cerelated measurements and coronary plaque progression have not been studied. We performed a retrospective analysis of 2,566 statin-treated patients with angiographic coronary artery disease who underwent serial evaluation of atheroma burden with intra- vascular ultrasound. Relations between achieved levels of HDL-related measurements with clinical characteristics and changes in plaque burden were determined. A strong correlation between HDL-C and apoA-I (r [ 0.80, p <0.001) was observed. HDL-C, apoA-I, and the HDL-C:apoA-I ratio demonstrated negative correlations with the change in percent atheroma volume and total atheroma volume (all p £0.001). Increasing levels of achieved HDL-C:apoA-I (p [ 0.04), but not HDL-C (p [ 0.18) or apoA-I (p [ 0.67), were asso- ciated with less progression of percent atheroma volume. Similar results were seen for change in total atheroma volume, with less progression seen with increased HDL-C:apoA-I (p [ 0.002)