Relieving visceral hyperalgesia effect of Kangtai capsule and its potential mechanisms via modulating the 5-HT and NO level in vivo》.pdf

Phytomedicine 20 (2013) 249–257 Contents lists available at SciVerse ScienceDirect Phytomedicine j o u r na l h o me p ag e: w w w. elsev ier.de/phymed Relieving visceral hyperalgesia effect of Kangtai capsule and its potential mechanisms via modulating the 5-HT and NO level in vivo Yun-Long Chen a,1, Xiao-Qi Huang a,1, Shi-Jie Xu b , Jin-Bin Liao a , Ru-Jun Wang b , Xiao-Feng Lu a , You-Liang Xie a , Fu-Sheng Zhou b,c,∗ , Zi-Ren Su a,c,∗∗ , Xiao-Ping Lai a,c a School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China b Institute of Digestive, Guangzhou University of Chinese Medicine, Guangzhou 510006, China c Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan 523808, China a r t i c l e i n f o a b s t r a c t Keywords: Kangtai capsule (KT) is one type of traditional Chinese medicine preparation derived from the proved Kangtai capsule recipe, which was frequently applied as an effective clinical treatment of IBS. However, there still lack the Fingerprint reasonable and all-round analytical approach and the scientific studies on its underlying mechanisms. Visceral hypersensitivity Therefore, our study aimed to develop the novel method for evaluating its quality as well as to interpret Neonatal maternal separation 5-HT the potential mechanisms. In our study, high performance liquid chromatography (HPLC) fingerprint was NO