老年性痴呆脑微血管发病机制通心络干预与研究.pdf

≯·气’ 目 录 中文摘要……………………………………………………………………1 英文摘要……………………………………………………………………8 英文缩写……………………………………………………………………18 研究论文老年性痴呆脑微血管发病机制及通心络干预研究 引言……………………………···………···………………···……19 第一部分老年性痴呆模型记忆和认知功能减退及通心络干预研究 前言·········…···……···…····…·····…···………···……····…·…····21日IJ舌”””””””””“““““一“一““”“”“““””“””””””一“一”“Zl 材料与方法……………………………………………………………21 结果………………······…··…………··…··················…···········25 附图、附表……………………………………………………………26 讨论········……·…···………………………………·····…···……····30 小结··…··…··················································”················37 参考文献………………………………………………………………37 第二部分老年性痴呆模型脑微血管损伤及通心络干预研究 O00···…………0”””“”””。 00OO 前言···…OOO 0······…······…······…···········…····41”””””“““一“一“…““””一”…”。4l 刖舌””一 材料与方法……………………………………………………………41 结果…········…··…····················································……·44 附图、附表……………………………………………………………46 讨论·······························…······································……54 小结·········…………·····………………····················…·····……55 参考文献………………………………………………………………56 第三部分Ap诱导脑微血管内皮细胞损伤及通心络干预研究 前言······……···……···……···…···…···……···………·…··………58刚舌”“””““““一””””一”“一…””””””一”””…””…”………，芍 材料与方法…………………………………………………………58 结果·····………·····…··…···········································……一65 附图、附表……………………………………………………………67 讨论····……····-·……·················································……·74 爿、结···············…·-·····…···……·…………·····················……-76 参考文献………………………………………………………………76 第四部分Ap损伤脑微血管内皮细胞对脑神经元的影响及通心络干预研究 前言………………………………………………···“·…o刖舌””““”””“““一””一“……””…“””““””“““ ooooo………79“”…一／y 材料与方法……………………………………………………………79 结果······…………………··································…··············85 o o o………………………………………………87 附图、附表………moo 讨论…·······················