神经肽Y和阻塞性睡眠呼吸暂停低通气综合征所致高血压的相关性.pdf

只0．01)。 降幅度与血浆NPY下降幅度亦呈正相关(r--O．418，P：-O．034)。 (O．850、-0．827、0．762，尸均O．01)。 7．所有实验对象MAP与NPY呈正相关(r=0．631，尺O．01)。 结论： 1．OSAHS患者血浆NPY浓度较正常对照组高，且与睡眠呼吸暂停现象的严重程 度相关，考虑OSAHS可引起血浆NPY浓度的升高。 2．所有观察对象的血压水平与血浆SPY浓度呈正相关，推测NPY与OSAHS所致 血压升高的发生发展有关。 3．经nCPAP治疗后，OSAHS患者血浆NPY浓度及平均动脉压均较治疗前有下降， 提示有效治疗OSAHS可以预防或减缓OSAHS所致高血压的发生、发展。 关键词：阻塞性睡眠呼吸暂停低通气综合征血压神经肽Y 6 betweenblood and A onthe pressure study relationship Y with patients neuropeptideamong plasma obstructive syndrome sleepapnea-hypopnea ABSTRACT ives Object of in To therole Y(NPY) investigate plasmaneuropeptide ofobstructive process sleepapnea—hypopneasyndrome physiopath0109ic (OSAHS)accompaniedbyhypertension． Methods with Afterthe patients overnight intotheOSAHS 30normal intothe OSAHSwere group，and subjects placed concentrationsof control plasma NPY，rightupper group．First，the arteriabrachialisblood index(AHI)， extremity pressure，apnea-hypopnea saturationof se timewhen of minimal pul oxygen(MinSp02)and percent measured nocturnalsaturationiowerthan90％(T—Sa0290％)were