《Screening and verification of ssDNA aptamers targeting human hepatocellular carcinoma.》.pdf

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《Screening and verification of ssDNA aptamers targeting human hepatocellular carcinoma.》.pdf

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／ ActaBiochimBiophysSin2014，46：128—135I@TheAuthor2013PublishedbyABBSEditorailOfficeinassociationwithOxofrdUniversityPressonbehalfoftheInsttiute ofBiochemistryandCellBiology,ShanghaiInstitutesforBiologicalSciences，ChineseAcademyofSciencesDOl：101093／abbs／grnt130 A AdvanceAccessPublicaliOn2December2013 OriginalArticle ScreeningandverificationofssDNA aptamerstargetinghumanhepatocellular carcinoma BinLu1T，JiucunW ang2T， JunZhangI，XiaojiaoZhang3，DongqinYang，LijunWu，ZhongguangLuo，YanyunMa， QiZhang，YunfangMa，XiaoyuPei，HuaYu，andJieLiu， DepartmentofDigestiveDiseasesofHuashanHospital，FudanUniversity，Shanghai200040，China MinistryofEducationKeyLaboratoryofContemporaryAnthropologyandStateKeyLaboratoryofGeneticEngineering．School0fLifeSciences FudanUniversity．Shanghai200433．China InstitutesofBiomedicalSciencesandDepartmentofImmunologyofShanghaiMedicalSchool，FudanUniversiyt，Shanghai200032，China DepartmentofCancerImmunotherapeuticsandTumorImmunology，BeckmanResearchInstiutteandCityofHopeComprehensiveCancer Center．Duarte，CA 91010，USA Tlleseauthorscontributedequallytothiswork． *Correspondenceaddress．TelF／ax：+86—21E—mail：iieliu@fudan．edu．cn Hepatocellularcarcinoma(HCC)isoneofthemostmalig- surveillanceandearlydiagnosisofHCC 2『，31．Becauseof nantcancersintheworid．Molecularprobesthatcanrecog- thelackofaccuratediagnosticmethods，mostHCCcasesare nizebiomarkersspecificforHCC areurgently neededto detectedatintemr ediateoradvancedstages，andthethem— improvethesensitivity and specificity ofearly diagnosis． peutice所 cacyisunsatisfactory．Inthiscontext．identifica— A recentstudyhasappnedthemethodofsystematicevolution tion ofnovelcancer-specificbiomarkersisessentialtothe ofHgandsbyexponentialenrichmentandproducedseveral detectionofsmallHCCandtotheimprovemento