《ApoAI 基因rs12721026多态性与长沙汉族人群脑出血的关系及其对血脂的影响 Association of ApoAI gene rs12721026 polymorphism with cerebral hemorrhage in Changsha Han population and its effect on plasma lipid levels》.pdfVIP

中南大学学报（医学版） 2013, 38(10) ; J Cent South Univ (Med Sci) 991 DOI:10.3969/j.issn.1672-7347.2013.10.003 /xbwk/fileup/PDF/201310991.pdf ApoAI 基因r态性与长沙汉族人群脑出血 的关系及其对血脂的影响 刘宝琼 ，杨期东，王红星，曾艺，胡中扬，马明明，张乐1 1 1 2 1 1 1 (1. 中南大学湘雅医院神经内科，长沙 410008；2. 中南大学湘雅二医院老年病科，长沙 410011) [摘要]目的：探讨载脂蛋白AI(apolipoprotein AI，ApoAI)基因r核苷酸多态性与长沙地区汉族人群脑出 血及血脂水平的关系。方法：利用单碱基延伸技术与DNA测序结合相互印证的方法检测长沙地区汉族人群273例脑出 血患者及140例正常对照的ApoAI基因r核苷酸多态性。采用氧化酶法测定三酰甘油(TG)、总胆固醇(TC)、 HDL-C及LDL-C水平。结果：脑出血组ApoAI基因r态基因型及等位基因频率分布与对照组比较差异无统 计学意义(P0.05)；脑出血组及对照组TT基因型亚组的HDL-C水平明显高于GT/GG基因型亚组(P0.05)，两组不同基 因型亚组间TG，TC，LDL-C水平差异无统计学意义(P0.05)。结论：ApoAI基因r态性可能与长沙地区汉 族人群脑出血的发病无关，但可能影响其HDL-C水平 。 [关键词] 载脂蛋白AI；基因多态性；脑出血；血脂 Association of ApoAI gene rpolymorphism with cerebral hemorrhage in Changsha Han population and its effect on plasma lipid levels 1 1 1 2 1 1 1 LIU Baoqiong , YANG Qidong , WANG Hongxing , ZENG Yi , HU Zhongyang , MA Mingming , ZHANG Le (1. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008; 2. Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China) ABSTRACT Objective: To explore the association between apolipoprotein AI (ApoAI) gene r polymorphism and cerebral hemorrhage (CH) in Changsha Han population, and to evaluate the effect of rpolymorphism on plasma lipid levels. Methods: A total of 273 patients with CH and 140 healthy controls were collected. The r