《HBV衣壳蛋白装配抑制剂的研究进展 Advances in Capsid Assembly Inhibitor of Hepatitis B Virus》.pdfVIP

ofAnhui 责任编辑陈玉敏责任校对况玲玲 安徽农业科学，Journal A扣．Sci．2014，42(10)：2915-2920 HBV衣壳蛋白装配抑制剂的研究进展 唐柳迪1，张玉强2，张玉彬1+(1．中国药科大学生物化学教研室，江苏南京210009；2．上海药明康德新药开发有限公司，上海 200131) 一 摘要乙型肝炎病毒(HBV)是一种常见的嗜肝性病原体，全球约有4亿人感染，带来严重的社会问题和经济负担。虽然目前已有预防 和治疗HBV的药物，但由于耐药性等问题不能彻底清除病毒感染，新药开发依然迫在眉睫。介绍了HBV的病毒结构、复制和感染过 程，对现有治疗药物的优缺点进行了总结。对以衣壳蛋白装配为靶点的新药研究进展进行综述，旨在为今后开发抗HBV的新药提供 参考。 关键词 乙型肝炎病毒；核苷类似物；干挽素；衣壳蛋白装配抑制剂 中图分类号$855．3文献标识码A 文章编号0517—6611(2014)10-02915—06 Advancesin Inhibitorof BVirus CardAssembly Hepatitis TANG Yu．Binet of Pharmaceutical Liu．di．z】}IANG al(DepartmentBiochemistry，ChimUniversity。Nanjing，Jiangsu210009) a causessevereso— AbstractWith 400million worldwideinfeetedwith Bvirus．itiS common which approximatelypeople hepatitis hepadnavirus the andtreatmentofchronic BvirusinfectionsiS availa— economicburdens．Antivirald】m祭for ciologyprobleln$and prevention hepatitis currently curevirusinfectionbecauseofdrawbacks and ofnoveliS ble．buttheyrarely exampledbydrugresistance．Therefore，discoverydevelopmentdrugs still this andinfeetion were anddisad- urgent．Inreview，viralstructure。HBVreplication proceduresbrieflyintroduced．Meanwhile，theadvantages of summarized．At advancesintermsofnovel anti—HBVwero vantagescurrentlyapproved drugs last，research anti—HBV峪targetingcapsid werereviewedin to referencesforthe ofnovelanti—HBVinthefuture． order drugs assembly providecomprehensive development words B