《COX-2与结直肠癌的临床病理参数及5-FU敏感性之间的关系》.pdfVIP

理岱胜疸匡堂至Q!兰生垒旦 箜丝鲞笠垒翅 丛Q旦垦曼堕Q盟堡Q垦Q鱼!：垒巳!：呈Q!垒：yQ坠：丝：堕Q：Q堡 ’869· COX一2与结直肠癌的临床病理参数及5一Fu敏感性之间的关系 觅1，任伟1，钱晓萍1 章群1，胡 静1，沈 洁1，刘宝瑞1，管文贤2，禹立霞1，杨 between and Correlation C¨niCaIpafhOlogiCaI cyclooxygenase一2 to5——FUinhumancolorectalcancer sensitivity Jiel，LiuBaoruil，GuanWenxian2，YuLixial，YangMil，RenWeil，QianXiaopin91 ZhangQunl，HuJin91，Shen 1 Cancer General Tower School The Centre；2 ofNanjing Comprehensive Departmentof Surgery，DrumHospital，Medical 210008，China． Nanjing the ofCOX一2anditscorrelationwith charac— 【Abstract】0bjective：Toinvestigateexpression clinicalpathological collected colorec— teristiesandchemosensitivitvto5一FUinhumancolorectalcancer．Methods：We freshly—removed 100 to5一FUwasdeterminedhistocuhure taltumor from patients．Chemosensitivity by drugresponseassay specimens correlationbetweenCOX一2 and were (HDRA)．The expressionclinicalpathologicalparametersanalysed．Results： TheCOX一2 wascorrelatedwithTNM and to5一 invasion，differentiationchemosensitivity expression stage．neural withtumormetastasisand the FU．Conclusion：TheCOX一2 levelisassociated expression stage，andoverexpression inclolorectalcancerwereassociatedwiththe to5一FU． ofCOX一2 chemosensitivity cance