《Enzymatic Synthesis and Characterization of Novel Amphiphilic Triblock Copolymer Poly(p-dioxanone-co-5-benzyloxytrimethylene carbonate)-block-poly(ethylene glycol)》.pdfVIP

Chinese Chemical Letters Vol. 17, No. 8, pp 1113-1116, 2006 1113 /journal/ccl.html Enzymatic Synthesis and Characterization of Novel Amphiphilic Triblock Copolymer Poly(p -dioxanone- co-5–benzyloxytrimethylene carbonate)- block-poly(ethylene glycol) Hua Li JIA, Feng HE*, Jun FENG, Ren Xi ZHUO Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072 Abstract: Novel amphiphilic triblock copolymer poly(p -dioxanone-co-5-benzyloxytrimethylene carbonate)-block-poly(ethylene glycol)-block-poly(p -dioxanone-co-5-benzyloxytrimethylene car- bonate) (p(PDO-co-BTMC)-b-PEG-b-p(PDO-co-BTMC)) was successfully synthesized using immobilized porcine pancreas lipase on porous silica particles (IPPL) as the catalyst for the first time. 1H NMR, 13C NMR and GPC analysis were used to confirm the structures of resulting copolymers. The molecular weight (Mn) of the copolymer with feed ratio of 69:20:11 (BTMC: PDO: PEG ) was 31300 g/mol and the polydispersity was 1.85, while the Mn decreased to 25000 g/mol and polydispersity of 1.93 with the feed ratio of 50:40:10. Keywords: Amphiphilic copolymer, poly(ethylene glycol), 5-benzyloxytrimethylene carbonate, p -dioxanone, enzymatic polymerization. In recent years, amphiphilic block copolymers consisting of hydrophilic and hydrophobic segments have attracted much attention, because of their unique phase behavior in aqueous media and potential applications as drug delivery systems1. Poly(ethylene glycol) (PEG), which have excellent properties in