《HBeAg阳性慢性乙型肝炎患者血清学转换与OAS基因多态性的关联分析》.pdfVIP

1270 论著／病毒性肝炎 HBeAg阳性慢性乙型肝炎患者血清学转换与 OAS基因多态性的关联分析 任姗，黄雁翔，马丽娜，金怡，何智敏，张晓丹，陈新月 (首都医科大学附属北京佑安医院国际医疗部，北京100054) 因内含子区rs2285934(A／C)位点、OAS2基因外显子一2区，rs2072138l IFNa治疗HBsAg转换，其单体型可作为获得HBeAg转换的预测因素。 关键词：肝炎，乙型，慢性；干扰素仅；多态性，单核苷酸；2’，5’寡腺苷酸合成酶 中图分类号：11512．6+2文献标识码：A 文章编号：1001—5256I加11)12—1270—05 ’I．1Ieassociationofthe ofinterferon—inducibleoAsandtheseroconversionof and study polymorphisms genes HBsAg in wim chronic Binfection interferon—aandnucleofide positive receiving HBeAgpatientsHBeAg hepatitis analogue combined therapy PEN Medwd MedicalUniversi- Shan，HUANG Li一加，etaL(International Yah—xiang，MA Department，＆舛昭You’肌Hospital，Capital 100054，China) ty，Beijing roleof nueleotide Toevaluatethe host Abstract：Objective single polymorphisms(SNPs)of2’，5’一oligoadenylate IFN in with chronicHBVinfection．Methods0AS andfourSNPswereexamined response HBeAg—positive gene in predicting patients 277 with HBVinfectionwhoweretreatedwithIFNdandNueleotide chronic effects patientsHBeAg—positive basedon and in seroconversion seroconversion wereevaluated HBsAgHBeAgseroconversion，resultingHBsAg group，HBeAg group，and withself HBVinfectionWaSselected船contr01．ResultsPatientsreached non—response(NR)group．50persons limiting versionwere seroconve瑁ionwere ofOAS3Callelerevealed