《Multi-component synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N-oxides》.pdfVIP

Available online at Chinese Chemical Letters 21 (2010) 927–930 /locate/cclet Multi-component synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N-oxides E. Rajanarendar *, M. Nagi Reddy, K. Rama Murthy CH_NE5E Department of Chemistry, Kakatiya University, Warangal 506009, A.P., India Received 17 December 2009 Abstract A three component one-pot protocol was investigated for the synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N-oxides from commercially available materials. # 2010 E. Rajanarendar. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. Keywords: Multi-component synthesis; Knoevenagel condensation; Michael addition; New methodology Multi-component reactions (MCRs) have proved to be remarkably successful in generating products in a single synthetic operation [1] and are important owing to their synthetic efficiency [2]. In times, where a premium is put on speed, diversity and efficiency in the drug discovery process [3], MCR strategies offer significant advantages over conventional linear-type syntheses. MCRs contribute to the requirements of an environmentally friendly process by 口HEM_CAL reducing the number of synthetic steps, energy consumption and waste production. Various biological applications have been reported for isoxazoles such as antitumor [4], CNS-active [5], analgesic [6], antimicrobial [7] and chemotherapy [8]. Isoxazoles display a wide range of organic reactivities and could be us