《Synthesis and In Vitro Antiviral Activities of Some New 2-Arylthiomethyl-4-tertiaryaminomethylsubstituted Derivatives of 6-Bromo-3-ethoxycarbonyl-5-hydroxyindoles》.pdfVIP

Chinese Chemical Letters Vol. 15, No. 1, pp 19 – 22 , 2004 19 /journal/ccl.html Synthesis and In Vitro Antiviral Activities of Some New 2-Arylthiomethyl-4-tertiaryaminomethylsubstituted Derivatives of 6-Bromo-3-ethoxycarbonyl-5-hydroxyindoles Dun WANG , De Sheng YU, Fang QIN, Lin FANG, Ping GONG* Shenyang Pharmaceutical University, Shenyang 110016 Abstract: Some new derivatives of 3-ethoxycarbonyl-6-bromo -5-hydroxyindoles were designed and prepared, their antiviral activity were determined in cell culture with virus cytopathic effect assay. The results showed compound b, h exhibited potential antiviral activity. Keywords: 3-Ethoxycarbonyl-6-bromo -5-hydroxyindoles, antiviral, synthesis. Influenza virus infection and acute respiratory viral infection (ARVI) remain a serious seasonal health concern. In this connection, chemotherapy is of great importance in the treatment of influenza and ARVI. Substituted 6-bromo -3-ethoxycarbonyl-5-hydroxyindoles have been known to exhibit various biological activities such as antiviral activity for influenza virus, interferon-inducing effects and so on1~4. Abidol 1 has been developed and licensed for the treament and prophylaxis of influenza and other acute respiratory viral infection in 5 Russia . Hence, with Abidol as the leadi