superficialnecrolyticdermatitisinadog.acasereportand.docVIP

ISRAEL JOURNAL OF ? VETERINARY MEDICINE?? SUPERFICIAL NECROLYTIC DERMATITIS IN A DOG. A CASE REPORT AND REVIEW OF THE LITERATURE Waner T.1*, Anug A.M.2, and Aizenberg I.3 1. Veterinary Clinic, 9 Meginay Hagalil Street, Rehovot 76200, Israel. wanertnt@shani.net2. PathoVet, 137 Shikun Banim, Kfar Bilu, 76965, Israel.3. Koret School of Veterinary Medicine, Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel. ?*Corresponding author: Abstract: This report describes a case of superficial necrolytic dermatitis (SND) in an 11-year old Schipperke female spayed dog. The report includes the clinical presentation follow-up, clinical chemistry, histopathology and ultrasound findings. A diagnosis of SND was based on clinical presentation, clinical chemistry, ultrasound examination and supported by the histological findings of parakeratosis, acanthosis, basal cell hyperplasia and epidermal edema. The dog also developed renal failure two months after initial presentation, a finding that has not been reported previously. A review of the literature is presented including comparative aspects of the disease in cats, rhinocerus and humans. ? Introduction: Superficial necrolytic dermatitis (SND) is a rare and fatal disease of dogs characterized by typical skin lesions accompanied by hepatopathy, and uncommonly glucagonomas of the pancreas (1). The condition is also known as hepatocutaneous syndrome, metabolic epidermal necrosis and necrolytic migratory erythema. The pathogenesis appears to be related to an underlying metabolic hepatic dysfunction bringing about a cutaneous nutritional depravation, leading to necrotizing skin disease (2). This condition is unusual in being one of the relatively few skin conditions in which a diagnosis can be made from a skin biopsy (2). This report describes a case of SND in an 11-year old female spayed dog. The report includes the clinical presentation, clinical chemistry and ultrasound findings. A review of the literature is also p