2型糖尿病患者血清NGAL水平与早期糖尿病肾病的关系.docVIP

2型糖尿病患者血清NGAL水平与早期糖尿病肾病的关系 赵璇 郭常辉 张晓娟 晏丕军 (重庆医科大学附属第二医院内分泌科，重庆400010) 【摘要】 目的 探讨2型糖尿病（Type 2 diabetes mellitus,T2DM）患者血清中性粒细胞明胶酶相关脂质运载蛋白Neutrophil gelatinase-associated lipocalin，sNGAL）水平与早期糖尿病肾病（Diabetic nephropathy，DN）的关系。方法 测定23例健康对照者，30例单纯2型糖尿病患者、36例早期糖尿病肾病患者的血清NGAL水平，将sNGAL水平与体重指数（BMI）、腰臀比（WHR）、胰岛素抵抗指数（HOMA-IR）、UAER、FBG、hs-CRP之间进行相关分析。结果 早期肾病组血清NGAL水平高于单纯糖尿病组及正常对照组（265.4±17.5vs208.9±13.9vs50.6±6.7ng/L,P0.05和P0.01）。sNGAL水平与空腹血糖（FPG）、超敏C反应蛋白(hs-CRP)、24小时尿白蛋白排泄率（UAER）、胰岛素抵抗指数(HOMA-IR)呈正相关（P分别0.05,0.01,0.05,0.05）。结论 早期DN患者sNGAL水平明显升高，NGAL可能在DN的发生发展中起了一定的作用。 【关键词】2型糖尿病；中性粒细胞明胶酶相关脂质运载蛋白The relationship between serum Neutrophil gelatinase-associated lipocalin level and diabetic nephropathy Zhao Xuan,Guo Chang hui,Zhang Xiao juan,et al. (Department of Endocrinolgy,the Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China.) 【Abstract】Objective To investigate the relationship between serum Neutrophil gelatinase-associated lipocalin (NGAL) and the early stage of diabetic nephropathy. Method 23 healthy subjects of control group,30 T2DM patient,36 early stage of diabetic nephropathy patient were selected.The serum level of NGAL was measured in each group.The correlations between sNGAL and BMI,WHR,HOMA-IR, FPG,hs-CRP were analysised. Result The sNGAL levels in patient with DN were significantly higher than that in control and T2DM groups.There were positive correlation between the sNGAL and FPG,hsCRP, HOMA-IR, UAER(P0.05 or P0.01). Conclution The serum level of NGAL is increased in the early stage of DN group.NGAL may play a great role in the development of diabetic nephropathy. 【Key words】 Type 2 diabete mellitus；sNGAL；early stage of Diabetic nephropathy 通讯作者 郭常辉，女，硕士生导师，主任医师，主要从事糖尿病及并发症的研究,TELEmail xiaoyu5798@126.com 第一作者 赵璇，女，在读硕士，主要从事糖尿病及并发症的研究，TEL糖尿病肾病（Diatebic Nephropathy，DN）是糖尿病最常见的微血管并发症之一，在美国，终末期肾病患者中糖尿病肾病患者占了30-40%[1],目前认为糖尿病肾病早期(微量白蛋白尿期)肾脏的病理改变多数是可逆的，如能早期诊断与治疗，可阻止病情向不可逆的终末期肾病发展，这对提高患者生存质量和减轻社会医疗经济负担具有重大意义。当