组蛋白甲基化修饰效应分子的研究进展.PDFVIP

See discussions, stats, and author profiles for this publication at: /publication [Advances in effector protein of histone methylation]. ARTICLE in H R DITAS (B IJING) · APRIL 2011 DOI: 10.3724/SP.J.1005.2011.00285 · Source: PubMed R ADS 330 2 AUTHORS, INCLUDING: Wei-Guo Zhu Peking University 66 PUBLICATIONS 3,899 CITATIONS S PROFIL Available from: Wei-Guo Zhu Retrieved on: 16 January 2016 HEREDITAS (Beijing) 2011 4 , 33(4): 285 ―292 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2011.00285 组蛋白甲基化修饰效应分子的研究进展 宋博研, 朱卫国 , 100191 作为一种重要的表观遗传学调控机制, 组蛋白甲基化修饰在多种生命过程中发挥了重要的作用。细胞内 有多种组蛋白甲基化酶和去甲基化酶共同调节组蛋白的修饰状态, 在组蛋白甲基化状态确定后, 多种效应分子 特异的读取修饰信息, 从而参与基因转录调控过程。文章从组蛋白甲基化效应分子的作用机制方面综述了这一 领域的研究进展。 表观遗传学; 组蛋白修饰; 组蛋白甲基化修饰效应蛋白; 基因转录调控 Advances in effector protein of histone methylation SONG Bo-Yan, ZHU Wei-Guo Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing 100191, China Abstract: As a significant epigenetic regulation mechanism, histone methylation plays an important role in many biologi- cal processes. In cells, there are various histone methyltransferases and histone demethylases working cooperatively to regulate the histone methylation state. Upon histone modification, effector proteins recognize modification sites specifically, and affect gene transcriptional process. This review mainly focuses on recent advances in histone methylation effector pro- tein’s function mechanism. Keywords: epigenetics; histone modification; effector protein of methylated histone; gene transcription regulation