L-脯氨酸催化的杂环化合物的合成研究进展有机化学.pdfVIP

DOI: 10.6023/cjoc201210033 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW L-脯氨酸催化的杂环化合物的合成研究进展 汪辉员 李丽丽 林 伟 黄志斌* 史达清* (苏州大学材料与化学化工学部 江苏省有机合成重点实验室 苏州 215123) 摘要 杂环化合物在医药、农药、材料等领域具有广泛的应用价值, 其合成方法研究是目前有机合成的研究热点之一. L-脯氨酸及其衍生物是一种易得的有机小分子催化剂, 在许多重要有机反应中取得了非常好的催化效果. 综述了近几 年 L-脯氨酸催化的杂环化合物的合成研究进展. 大多合成方法具有反应条件温和、回处理方便、产率高、环境友好等 优点. 关键词 L-脯氨酸; 杂环化合物; 合成; 应用 Progress in Application of L-Proline in Catalyzing the Synthesis of Heterocyclic Compounds Wang, Huiyuan Li, Lili Lin, Wei Huang, Zhibin* Shi, Daqing* (College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Organic Synthesis of Jiangsu Province , Soochow University, Suzhou 215123) Abstract Heterocyclic compounds have shown many important applications in medicine, pesticide and materials. The syn- thetic method of heterocyclic compounds is one of the focused fields in organic synthesis. Small organic molecules like L-proline and its derivatives are readily commercially available catalyst and have been used in some important organic reac- tions. The applications of L-proline in catalyzing the synthesis of heterocyclic compounds in recent years are reviewed. Most mentioned synthetic methods have the advantages of mild reaction conditions, easily operation, high yields and environmen- tally friendly. Keywords L-proline; heterocyclic compound; synthesis; application L-脯氨酸(L-Proline 简写 L-Pro)又称 L-吡咯烷-2-羧 水萃取即可很容易除去, 反应的后处理十分方便. 使得 酸, 氢化吡咯甲酸, 是一种含吡咯烷的亚氨酸. L-脯氨 它作为催化剂在有机合成中的得到了越来越广