Lewis酸催化下苯乙酮型苯并吡喃的合成有机化学.pdfVIP

2010 年第 30 卷 有 机 化 学 Vol. 30, 2010 第 12 期, 1944～1948 Chinese Journal of Organic Chemistry No. 12, 1944～1948 ·研究简报· Lewis 酸催化下苯乙酮型苯并吡喃的合成 齐小燕 a 伍 林*,a 王建国 a,b 易德莲 a 周锦霞 a 刘 敏 a 彭功名 a (a 武汉科技大学应用化学研究所 武汉 430081) (b 九江学院化学化工学院 九江 332005) 摘要 以2,4-二羟基苯乙酮(1a)为原料, 通过 O-异戊烯基化和 Lewis 酸催化分子内关环反应, 合成了苯乙酮型苯并吡喃 化合物 3a. 产物结构经 UV, IR, 1H NMR, 13C NMR 和元素分析表征, 并对反应条件进行了初步探讨. 关键词 O-异戊烯基化; 苯并吡喃; Lewis 酸; 合成 Synthesis of Acetophenone Benzopyran Derivative Catalyzed by Lewis Acids Qi, Xiaoyana Wu, Lin*,a Wang, Jianguoa,b Yi, Deliana Zhou, Jinxiaa Liu, Mina Peng, Gongminga a ( Applied Chemistry Research Institute, Wuhan University of Science and Technology, Wuhan 430081) (b School of Chemistry and Chemical Engineering, Jiujiang University , Jiujiang 332005) Abstract A acetophenone benzopyran derivative was prepared from 1-(2,4-dihydroxyphenyl)ethanone (1a) through O-prenylation and Lewis acids catalyzed intramolecular cyclization reaction. The structure of 1 13 product 3a was characterized by UV, IR, H NMR, C NMR spectra and elemental analysis, and the reaction conditions were discussed. Keywords O-prenylation; benzopyran; Lewis acid; synthesis 苯并吡喃又称为色烯(chromene), 由苯和吡喃稠合 Christine 等从 Melicope Ptelefolia 的叶子中分离得到 d 而成[1].