双子季铵盐稳定的纳米钯催化Suzuki反应的研究有机化学.pdfVIP

2011 年第 31 卷 有 机 化 学 Vol. 31, 2011 第 6 期, 850～854 Chinese Journal of Organic Chemistry No. 6, 850～854 ·研究论文· 双子季铵盐稳定的纳米钯催化 Suzuki 反应的研究 * 周 波 李毅群 (暨南大学化学系 广州 510632) 摘要 双子座季铵盐能够稳定现场产生的纳米钯粒子, 该纳米钯粒子能有效地催化一系列芳基硼酸和芳基卤代烃发生 Suzuki 偶联反应. 双子座季铵盐稳定的纳米钯粒子能够在空气中稳定存在, 透射电镜(TEM)分析纳米钯粒子呈圆球形, 粒径分布在 5～25 nm. 该方法具有反应条件温和、反应时间短、后处理简单方便等优点. 关键词 Suzuki 反应; 纳米钯; 双子座季铵盐 Suzuki Reaction Catalyzed by Nanopalladium Stabilized by Gemini Quaternary Ammonium Salt Zhou, Bo Li, Yiqun* (Department of Chemistry, Jinan University , Guangzhou 510632) Abstract Palladium nanoparticles with the size ranged from 5 nm to 25 nm confirmed by transmission electron microscopy (TEM), generated in situ from the reaction of palladium(II) chloride and stabilized by Gemini quaternary ammonium salt, have been demonstrated to be an efficient catalyst for Suzuki car- bon-carbon cross coupling reaction. A variety of aryl bronic acids and aryl halides have been proceed smoothly to afford the corresponding biaryls in high yields by using palladium nanoparticles in the presence of potassium carbonate without any ligands. This protocol has the merits of that the catalyst is stable in air and the procedure of experiment is simple. Keywords Suzuki reaction; nanopalladium; Gemini quaternary ammonium salt 过渡金属催化交叉偶联反应是在有机合成中被广 纳米钯粒子的高催化活性和循环使用性能. 文献报道[9] 泛使用的一个有效手段, 尤其是钯催化下的 Suzuki 交叉