新型N-酰基-7-甲氧基-苯并[4,5]噻唑并[2,3-c][1,2,4]三唑-3(2H)-硫酮的合成及其除草活性有机化学.pdfVIP

DOI: 10.6023/cjoc201308001 研究简报 有机化学 Chinese Journal of Organic Chemistry NOTE 新型N-酰基-7- 甲氧基-苯并[4,5]噻唑并[2,3-c][1,2,4]三唑-3(2H)- 硫酮的合成及其除草活性 王海林 阮铃莉 陈 勇 刘幸海 翁建全* (浙江工业大学化学工程与材料学院 杭州 310032) 摘要 为了寻找新的含苯并噻唑稠杂环农药先导化合物, 以 2-氨基-6- 甲氧基苯并噻唑为起始原料, 经肼化、环化和酰 基化反应, 合成出了 14 个 N-酰基-7- 甲氧基苯并[4,5]噻唑并[2,3-c][1,2,4]三唑-3(2H)-硫酮, 并利用 1H NMR, ESI-MS 及 元素分析对其结构进行表征. 对目标化合物进行初步的除草活性筛选, 实验结果表明: 在浓度为 200 mg/L 时, 大部分 化合物对黄瓜(Cucumis sativus) 、小麦(Triticum aestivum) 、高粱(Sorghum vulgare) 、萝卜(Raphanus sativus) 、油菜(Brassica campestris)和稗草(Echinochloa crusgalli) 的根和茎的抑制率在 85% 以上. 关键词 N-酰基-7- 甲氧基苯并[4,5]噻唑并[2,3-c][1,2,4]三唑-3(2H)-硫酮; 合成; 除草活性 Synthesis and Herbicidal Activity of Novel N-Acyl-7-methoxybenzo[4,5]thiazolo- [2,3-c][1,2,4]triazole-3(2H)-thione Wang, Hailin Ruan, Lingli Chen, Yong Liu, Xinghai Weng, Jianquan* (College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032) Abstract In order to find the new fused heterocycle of benzothiazole lead compounds, fourteen novel N-acyl-7-methoxy- benzo[4,5]thiazolo[2,3-c][1,2,4]triazole-3(2H)-thiones were synthesized by using 6-methoxybenzo[d]thiazol-2-amine as starting materials via hydrazine, cyclization and acylation. The structures of the target compounds were characterized by 1H NMR, ESI-MS and elemental analysis. The synthesized target compounds were screened for the herbicidal act