新型取代3-芳基-1,2,4-三唑并[3,4-b]苯并噻唑的合成及其杀菌活性有机化学.pdfVIP

DOI: 10.6023/cjoc1111162 研究简报 有机化学 Chinese Journal of Organic Chemistry NOTE 新型取代3-芳基-1,2,4-三唑并[3,4-b]苯并噻唑的合成及其杀菌活性 翁建全*,a 黄 华a 谭成侠a 刘幸海a 储为盛a 陈 杰b a ( 浙江工业大学化学工程与材料学院 杭州 310032) (b 国家南方农药创制中心浙江基地生测部 杭州 310023) 摘要 为了寻找新的含苯并噻唑稠杂环农药先导化合物, 利用取代 2-肼基苯并噻唑与取代苯甲酸在三氯氧磷中回流反 应, 合成了 18 个新型取代 3-芳基-1,2,4-三唑并[3,4-b]苯并噻唑化合物, 并利用 1H NMR, EI-MS 及元素分析对其结构进 行了表征. 初步生物活性试验结果表明, 在 50 mg/L 浓度下, 部分目标化合物对立枯丝核菌(Rhizoctonia solani) 、西瓜壳 二孢菌(Ascochyta citrullina) 、香蕉枯萎病菌(Fusarium oxysporum f.sp. cubense)、烟草炭疽病菌(Colletotrichum nicotianae) 具有中等杀菌活性. 然而, 部分化合物对灰葡萄孢菌(Botrytis cinerea)反而起到一定促进生长作用. 关键词 1,2,4-三唑并[3,4-b]苯并噻唑; 合成; 杀菌活性 Synthesis and Antifungal Activity of Novel Substituted- 3-aryl-1,2,4-triazolo[3,4-b]benzothiazoles Weng, Jianquan*,a Huang, Huaa Tan, Chengxiaa Liu, Xinghaia Chu, Weishenga Chen, Jieb (a College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032) b ( Bioassay Department, Zhejiang Branch of National Southern Pesticide Research Centre, Hangzhou 310023) Abstract In order to find new benzothiazole lead compounds, eighteen new substitued-3-aryl-1,2,4-triazolo[3,4-b]-benzo- thiazoles were synthesized by reacting substituted-2-hydrazinobenzothiazole with various substituted benzoic acids in POCl3 under reflux condition. The structures of the title compounds were characterized by 1H NMR, EIMS techniques and elementa