新型含2-取代-1,3-噻唑烷的查尔酮类化合物的合成及其生物活性有机化学.pdfVIP

DOI: 10.6023/cjoc1202211 研究论文 有机化学 Chinese Journal of Organic Chemistry ARTICLE 新型含2-取代-1,3-噻唑烷的查尔酮类化合物的合成及其生物活性 戴 红*,a,b 苗文科a 刘建兵a 吴珊珊a 秦 雪a 方建新*,a (a 南开大学元素有机化学国家重点实验室 天津 300071) (b 南通大学化学化工学院 南通 226019) 摘要 为了寻找生物活性良好的查尔酮类化合物, 利用2-(2-氰基亚胺基-1,3-噻唑烷-3-基)-1-苯基乙酮或3-((2-氰基亚胺 基-1,3-噻唑烷-3-基)-1-苯基-1-丙酮与取代苯甲醛发生缩合, 合成了 14 个新型含 2-取代-1,3-噻唑烷的查尔酮类化合物. 1 其结构均经 H NMR 和元素分析表征. 初步的生物活性测试结果表明, 在试验浓度下, 部分目标化合物表现出一定的 杀菌活性. 关键词 查尔酮; 1,3-噻唑烷; 合成; 生物活性 Synthesis and Biological Activity of Novel Chalcone Derivatives Containing 2-Substituted-1,3-thiazolidine Ring Dai, Hong*,a,b Miao,Wenkea Liu, Jianbinga Wu, Shanshana Qin, Xuea Fang, Jianxin*,a a ( State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071) b ( College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019) Abstract In order to find new chalcone derivatives with good biological activity, fourteen novel chalcone compounds con- taining 2-substituted-1,3-thiazolidine ring were synthesized by the reaction of 2-(2-cyanoimino-1,3-thiazolidine-3-yl)-1- phenylethanone or 3-(2-cyanoimino-1,3-thiazolidine-3-yl)-1-phenylprop-1-one with different substituted benzaldehydes. All the title compounds have been confirmed by 1H NMR spectra and elemental analysis. The preliminary bioassay showed that some target compounds displayed fung