有机催化不对称Henry加成反应有机化学.pdfVIP

2010 年第 30 卷 有 机 化 学 Vol. 30, 2010 第 12 期, 1811～1819 Chinese Journal of Organic Chemistry No. 12, 1811～1819 ·综述与进展· 有机催化不对称 Henry 加成反应 高书涛 a 郗国宏 a 李 宁 a,b 王 春 a 马晶军*,a (a 河北农业大学理学院 河北省生物无机化学重点实验室 保定 071001) (b 河北农业大学食品科技学院 保定 071001 ) 摘要 有机催化不对称合成反应是目前国内外研究最为活跃的领域之一. 不对称 Henry 反应是合成光学活性硝基化 物的有效手段, 目前报道的催化不对称Henry 反应的有机催化剂主要有手性胍、手性(硫)脲衍生物、金鸡纳碱衍生物等, 取得了良好的催化活性和对映选择性. 对各类有机催化剂在有机催化不对称 Henry 反应中的应用研究进展, 以及不对 称诱导反应的机理、催化剂的分子结构及反应条件对其催化活性和不对称诱导活性的影响进行了评述. 关键词 有机催化; 对映选择性; 不对称 Henry 反应 Organocatalytic Asymmetric Henry Reactions Gao, Shutaoa Xi, Guohonga Li, Ninga,b Wang, Chuna Ma, Jingjun*,a a ( Hebei Key Laboratory of Bioinorganic Chemistry, College of Sciences, Agricultural University of Hebei, Baoding 071001) (b College of Food Science and Technology, Agricultural University of Hebei , Baoding 071001) Abstract Organocatalytic asymmetric reaction is an increasingly active area in organic synthesis. Asym- metric Henry reaction is a versatile tool for the synthesis of chiral nitro compounds. The reported organo- catalysts for asymmetric Henry reaction include chiral guanidines, chiral (thio)urea derivatives, cinchona al- kaloids and so on, which could catalyze the asymmetric Henry reaction with high catalytic activity and ex- cellent enantioselectivity. The applications of various organocatalysts in asymmetric Henry reaction are re- viewed in this paper. The reaction mechanism, catalytic activity and the asymmetric induction influenced by the structure of organocatalyst